• To date no biomarker analyses of response to

  2019-06-05

  

  To date, no biomarker analyses of response to VEGFR targeting agents in breast cancer patients with bone predominant metastatic disease has occurred. Although the bone turnover markers serum c-telopeptide (sCTx), and urinary N-telopeptide (uNTx) were measured at baseline, and uNTX measured every 8 w

• The majority of breast malignancies are hormone responsive a

  2019-06-05

  

  The majority of breast malignancies are hormone responsive, and adjuvant endocrine therapy is used routinely to prevent breast cancer recurrence and death [6,7]. Tamoxifen was the past treatment of choice for endocrine-responsive postmenopausal breast cancer and was found to preserve BMD in postmeno

• br Es curioso observar que en el terreno de

  2019-06-05

  

  Es curioso observar que en el terreno de la crítica musical, la tarea fundamental es evidentemente depurar la teoría de todo aquello que obstaculiza la formulación precisa de los elementos esenciales de la música. Sin embargo, cuando se trata de estudiar el tema de la música en la literatura, nada

• Undoubtedly hydroxyurea has a huge

  2019-06-05

  

  Undoubtedly, hydroxyurea has a huge potential for improving the quality of lives of people affected by sickle-cell anaemia in settings where frequent and probably unsafe blood transfusions are the current standard of care. However, attention needs to be directed towards the potential adverse effects

• Desde otra perspectiva tendiente a debilitar las tesis

  2019-06-05

  

  Desde otra perspectiva, tendiente soluble guanylate cyclase debilitar las tesis de Ardao y de Rojas Mix, ese mismo año de 1998, Vicente Romero reconsideró la influencia sobre Bilbao de Lamennais e hizo gravitar sobre él el sentido suyo de la latinidad. Ese sentido sería el que pone en circulación el

• br We recently reported associations between

  2019-06-05

  

  We recently reported associations between maternal age at childbirth and outcomes in the offspring, using data from five birth cohorts (COHORTS collaboration) in low-income and middle-income countries (LMICs), in . Young maternal age ( Antimicrobial resistance is recognised as a serious global he

• HOBt br Conflict of interest br

  2019-06-05

  

  Conflict of interest Acknowledgments This research was supported by the Grants from the National Natural Science Foundation of China (No. 31270820 and No. 81230061 to Wei-Dong Han, No. 81402567 to Ya-jing Zhang) and was partially supported by a Grant from the National Basic Science and Develop

• ECG changes emerged when creating a

  2019-06-05

  

  ECG changes emerged when creating a substrate map of the LV (Fig. 2A), near the inferior mitral valve. A long transseptal sheath was introduced into the LV under intracardiac echocardiography guidance without causing an air-embolism. While performing the LV substrate mapping, the long transseptal sh

• br Sebastian Vollmer and colleagues April conclude that

  2019-06-05

  

  Sebastian Vollmer and colleagues (April, 2014) conclude that “the contribution of economic growth to the BIBW2992 in early childhood undernutrition in developing countries is very small, if it exists at all”. Progress will therefore require a shift from “the so-called trickle-down approach of a g

• La fotograf a reforz el car cter militarista del

  2019-06-01

  

  La fotografía reforzó el carácter militarista del pgt-pc. El ajusticiamiento de Zepeda Martínez perdió su fuerza política al carecer de los mecanismos de propaganda que acompañan una acción de este tipo. Si bien los recursos gráficos explotados por el periodismo difundieron direct renin inhibitors l

• br Discussion False tendons are usually benign intraventricu

  2019-06-01

  

  Discussion False tendons are usually benign, intraventricular myocardial structures, which may cause a musical murmur [1], rate-dependent ventricular extrasystoles, functional mitral regurgitation, or deformation of the LV cavity due to mechanical stretch and dilatation of the LV wall [1,2]. Fals

• Worldwide one in three women experience gender based

  2019-06-01

  

  Worldwide, one in three women experience gender-based violence, which imparts physical, mental, and sexual health morbidities. It also causes mortality—more than a third of homicides of women are attributable to male partners. These data justifiably create global outrage, accentuated by horrific rec

• En la obra de Cuadra una familia campesina confronta tr

  2019-06-01

  

  En la obra de Cuadra, una familia campesina confronta trágicamente la guerra civil entre conservadores y liberales. Víctimas pasivas de las élites y no actores políticos, estos campesinos ven cómo los principios familiares tradicionales y del minifundio son desarticulados por la guerra y el abuso de

• br As the global burden

  2019-06-01

  

  As the global burden of disease shifts from infectious diseases to non-communicable diseases (NCDs), cancer has increasingly become a major contributor to morbidity and mortality in low-income and middle-income countries (LMICs). Major reasons for these Manumycin A shifts include increasing life

• br Conflict of interest br Case presentation

  2019-06-01

  

  Conflict of interest Case presentation A 41-year-old man with a history of palpitations refractory to multiple antiarrhythmic agents for several weeks was referred to our department. A 12-lead electrocardiogram (ECG) demonstrated incessant narrow QRS complex tachycardia (cycle length of 580ms

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