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To establish precisely the relationships between cell lineag
2018-10-22
To establish precisely the relationships between cell lineages, cell identity must be defined at the branching point of these two hematopoietic lineages, and individual cells that are free of the influence of environmental signals should be analyzed. In the adult hematopoietic system, various differ
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Induced pluripotent stem cells iPSCs hold great promise for
2018-10-22
Induced pluripotent stem mgmt inhibitor (iPSCs) hold great promise for regenerative medicine (Lowry et al., 2008; Maherali et al., 2007; Okita et al., 2007; Park et al., 2008; Takahashi et al., 2007; Takahashi and Yamanaka, 2006; Wernig et al., 2007; Yu et al., 2007), but their underlying molecular
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Similar to our observation that Nanog
2018-10-22
Similar to our observation that Nanog−/− iPSCs could give rise to chimeric animals, Nanog null ESCs have been shown to contribute to the three germ layers (Chambers et al., 2007). However, in the case of ESC chimeras, Nanog−/− GFP+ ci-1033 were not detected in the germline after E12.5. Because the C
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As PcG proteins and miRNAs are usually co expressed
2018-10-22
As PcG proteins and miRNAs are usually co-expressed in many cell types or cancer tissues, such as keratinocytes (Eckert et al., 2011; Yi et al., 2008), hematopoietic stem buy FMK (Takamatsu-Ichihara and Kitabayashi, 2016), hepatocellular carcinoma (Yonemitsu et al., 2009), lung cancer (Chen et al.,
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In this study hPSC derived bfCNs were
2018-10-22
In this study hPSC-derived bfCNs were generated via an expandable NSC intermediate, which maintained the desired basal forebrain progenitor phenotype, and neurogenic capacity even after long-term expansion in culture. This scalability is a required feature of any cell type to be used in regenerative
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br Community demand and expectation Unfortunately
2018-10-20
Community demand and expectation Unfortunately, autologous stem cell therapies continue to be presented and viewed under a commercialistic social lens which remains insensitive to the medical professional norms just described. This makes it all too easy for clinicians to offer these treatments as
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CBP is implicated in different biological functions
2018-10-20
CBP is implicated in different biological functions with an essential role in maintaining normal germ cells development. CBP is expressed in primordial germ cells (PGCs) and in ESCs but is highly expressed in PGCs compared with ESCs. Proper levels of CBP have been shown to be important for hematopoi
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Using ESNPs to repair damaged tissue in neurodegenerative di
2018-10-20
Using ESNPs to repair damaged tissue in neurodegenerative diseases is an attractive option, as these direct renin inhibitors are more readily obtained than fetal material. Recent work on the relationship between neural stem cells and blood vessels (reviewed in (Bjornsson et al., 2015) as well as ou
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br Materials and methods br Acknowledgments We would like to
2018-10-20
Materials and methods Acknowledgments We would like to thank Dr. Saran Karumbayaram for providing guidance in the culture and expansion of the primate fibroblasts. We would also like to thank Steven Dowdy for depositing the T7-VEE-OKS-iG plasmid (Addgene). This project was funded by NIH grant
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The induced expression of hADC was confirmed
2018-10-20
The induced expression of hADC was confirmed by immunostaining and western blotting (Fig. 1A&B). The over-expression of hADC genes significantly increased endogenous agmatine (Fig. 1C). Adherence of histamine dihydrochloride is important for differentiation as well as for proliferation, migration,
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how to calculate dilutions http www apexbt com media diy ima
2018-10-20
br> Conclusion Acknowledgments This work was supported by Progetto PON - “Ricerca e Competitività 2007–2013” - PON01_01802: “Sviluppo di molecole capaci di modulare vie metaboliche intracellulari redox-sensibili per la prevenzione e la cura di patologie infettive, tumorali, neurodegenerative e
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These findings predict that Lgr CBCs
2018-10-20
These findings predict that Lgr5-CBCs must have a significantly shorter lifespan than the reserve ISCs; otherwise, an age-related accumulation of Lgr5-CBCs would result from the constant generation of CBCs from the reserve ISCs. Indeed, this finite lifespan of Lgr5-CBCs can be observed in prior stud
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Whereas most studies aiming at reprogramming brain resident
2018-10-20
Whereas most studies aiming at reprogramming brain-resident glia into neurons focused on astroglia, NG2 glia represent an interesting alternative cellular source given their abundance and life-long capacity for proliferation (Dimou and Götz, 2014). Here, we found that ∼60% of the induced DCX+ neuron
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Evidence suggests that sex steroids play at
2018-10-20
Evidence suggests that sex steroids play at least some role in age-related degeneration of lymphopoiesis (Chinn et al., 2012), and we, and others, have previously shown that sex steroid ablation (SSA) is able to rejuvenate aged and immunodepleted BM and thymus, enhance peripheral T and B cell functi
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Introduction The adult intestinal epithelium is a self
2018-10-20
Introduction The adult intestinal epithelium is a self-renewing tissue with a high turnover rate maintained by intestinal stem cells that reside at the AP1903 of glands (called crypts). Lgr5 (leucine-rich-repeat-containing G protein-coupled receptor 5), a Wnt/β-catenin target gene, exclusively mark
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