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The obtained results indicate that even when
2024-01-08
The obtained results indicate that even when the impairment of the same forms of memory are present, amnesia can develop in different ways. Impairment of memory reconsolidation in the conditioned food aversion model through both the serotonin receptor antagonist and the antagonist of NMDA glutamate
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Here we report discovery of highly selective pan Aurora kina
2024-01-08
Here we report discovery of highly selective pan-Aurora kinase inhibitors through phenotypic screening. The co-crystal structure of R 59-022 bound in the ATP binding site of Aurora A is described, and provides insight into the possible structural basis for the selectivity of the interaction. To i
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br Colorectal carcinoma The growth rate of murine
2024-01-08
Colorectal carcinoma The growth rate of murine colon adenocarcinoma tumors decreased upon inhibition of 5-LOX, an enzyme that harbors counteracting properties to 15-LOX [28]. It is not clear whether 15-LOX was associated with this phenomenon, but its expression is induced in the colon carcinoma c
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Two parallel branches of the DNA damage
2024-01-08
Two parallel branches of the DNA damage-dependent S-phase checkpoint are thought to co-operate by inhibiting distinct steps of DNA replication. One branch includes the phosphorylation of structural maintenance of chromosomes 1 (SMC1), a cohesin that is activated by ATM or ATR after IR treatment or r
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Nuclear/Cytosol Fractionation Kit br Materials and methods b
2024-01-08
Materials and methods Results Discussion In this study, the orphan receptor GPR25 was cloned from several representative vertebrate species including zebrafish. Although the overall amino Nuclear/Cytosol Fractionation Kit sequence identity among these species is not high (38–52%), our synt
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AP plays a pivotal role in transcriptional regulation of MMP
2024-01-08
AP-1 plays a pivotal role in transcriptional regulation of MMP expression. The decoy technique allows the neutralization of AP-1 without any transfection reagents for cellular uptake that cause potential side effects or immune reactions. This energy-dependent transport mechanism of “naked” dODN is c
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A disfun o cognitiva p s operat ria uma s
2024-01-05
A disfunção cognitiva pós‐operatória é uma síndrome perioperatória bem reconhecida, consequência da anestesia e cirurgia cuja causa exata permanece por esclarecer. De que forma KT 5720 disfunção cognitiva pós‐operatória e a doença de Alzheimer podem estar ligadas permanece uma questão em estudo. A b
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APPL is highly expressed in
2024-01-05
APPL1 is highly expressed in pancreatic β cells, but its levels are significantly decreased in several mouse models of obesity and diabetes, including HFD-induced obese mice and db/db mice [6], [73], suggesting that the dysregulation of APPL1 may be associated with malfunction of the pancreas in obe
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The results show that a tonic action
2024-01-05
The results show that a tonic action of ACh on respiration is lacking. However, it is clear that muscarinic cholinergic mechanisms can modulate both eupneic breathing and the cough reflex. When these mechanisms are brought into action is obscure and only tentative proposals can be advanced. ACh in t
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br The embryological and physiological roles
2024-01-05
The embryological and physiological roles of ATX ATX is a vital enzyme that is needed for early embryological development. ATX knockout (KO) (ENPP2−/−) embryos die in utero on average at day 9.5 with vascular and neural tube defects [30], [73], [74], [75]. In these mice, malformations in the alla
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Additionally in a previous transgenic model with autotaxin u
2024-01-05
Additionally, in a previous transgenic model with autotaxin under the control of the MMTV-LTR promoter, aberrant expression of human autotaxin caused late-onset, metastatic breast cancer [5]. The AT-ATX transgenic model is analogous to the previous one because ∼30% of all spontaneous tumors appeared
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The co crystal structure of
2024-01-05
The co-crystal structure of ()-blebbistatin ()- bound to myosin II (PDB: ) was used to scout for possible favorable interactions with the residues lining the binding pocket. Looking at A, we hypothesized that -oriented hydrophilic moieties (e.g. hydroxymethyl) on C of the blebbistatin scaffold might
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Use of antibiotics would be expected to alter the maternal
2024-01-04
Use of 3mb receptor would be expected to alter the maternal microbiome, thereby changing the infant's initial exposure is to the microbial environment, which could potentially lead to an abnormal succession of microbial colonization in the infant. Alterations in early microbial transfer and successi
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AR is an enzyme involved in conversion
2024-01-04
AR is an enzyme involved in conversion of glucose into sorbitol using NADPH as a cofactor [46]. This AR polyol pathway generates sorbitol accumulation and NADPH depletion. NADPH participates in detoxification via glutathione (GSH) reductase pathway [47]. Therefore, reduction of NADPH attenuates remo
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In this study we demonstrated that DRR protein level in
2024-01-04
In this study, we demonstrated that DRR1 protein level in GBM tissues was significantly higher compared to normal Quinacrine hydrochloride hydrate tissues. This data suggested that DRR1 might play a role in the tumorigenesis of glioma. To investigate whether DRR1 could accurately predict the outcome
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