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br Discussion Herein we demonstrate
2023-04-06
Discussion Herein, we demonstrate that mice deficient in L-12/15 LO are more sensitive to 3-NP-induced toxicity although a substantial individual variability in striatal lesion size in response to 3-NP in both genotypes was observed. This variability is not atypical; several studies demonstrate s
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Bleomycin Sulfate How does the ATM to
2023-04-06
How does the ATM-to-ATR switch occur at DSBs? The progressive attenuation of ATM activation could be attributed to the loss of DNA structures that activate ATM, or to the generation of DNA structures that interfere with ATM activation. Our finding that SSOs do not directly affect the binding of puri
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br Experimental and simulation section br Acknowledgments
2023-04-04
Experimental and simulation section Acknowledgments Financial support for this work was provided by the National Natural Science Foundation of China (No. 81101688). We would like to thank NC State University High Performance Computing Center for providing us computing resources, and Dr. Lihui
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br The role of apelin in cancer
2023-04-03
The role of apelin in cancer Studies on cancers are intensively conducted worldwide. It is thought that this large family of diseases is among the most studied. The researchers test newly-discovered substances hoping to find remedies and diagnostic indices for this illness. One of such substances
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br Materials and methods br Results and discussion br
2023-04-03
Materials and methods Results and discussion Conclusions Acknowledgements Introduction Infections in children aged 0–21 years who reside in long-term care (LTC) facilities are common due to underlying complex medical conditions, use of invasive devices such as urinary catheters and ve
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However joint reviews and the consensus from experts
2023-04-03
However, joint reviews and the consensus from experts offer disparate recommendations with regard to their management in the context of anesthesia, whereas some reviews [6], [7] set out certain doubts regarding their use during the perioperative period. On the other hand, the guidelines for the mana
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The biology of the A BR is complex
2023-03-28
The biology of the A2BR is complex and needs to be considered contextually as the expression and effect of receptor engagement varies according to time post hypoxic injury, cell type and downstream signaling pathway. For example, A2BR expression is dynamic - low under basal and increasing under isch
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Some alterations in the integrity of cell membranes caused b
2023-03-28
Some alterations in the integrity of cell membranes caused by toxic agents can be determined by measuring certain enzymes released by damaged cells [8]. The cholinesterases, for example, catalyze the hydrolysis of Anti-cancer Compound Library (ACh) in choline and acetic acid. Theses enzymes are div
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As summarized in Fig autophagy
2023-03-27
As summarized in Fig. 1, autophagy up-regulation in terms of Beclin 1 induction, increase of LC3 II and p62 down-regulation were observed between 24 and 72 h of cell incubation, this coinciding with the end of the period 27-OH caused slight reduction of cell viability and proliferation as previously
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Introduction Mitotic kinases play an
2023-03-27
Introduction Mitotic kinases play an essential role in mitosis, Aurora and other mitotic kinases are often observed over-expression in human solid and many hematologic cancers. As one of serine/threonine kinases, Aurora kinase family is involved in centrosome maturation, mitotic spindle formation,
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br AR expression in breast tissue Although androgenic
2023-03-23
AR expression in breast tissue Although androgenic signalling is chiefly associated with the development and maintenance of primary and secondary male characteristics, especially during puberty when the testes are by far the major source of testosterone, the AR also plays important functions in f
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Discussion The present experiments follow up and are
2023-03-23
Discussion The present experiments follow-up and are completely consistent with our prior findings [26] that blood Aβ is subject to peripheral clearance by a major pathway for circulating pathogens in primates, immune adherence [30,31]. CR1-mediated erythrocyte immune adherence, as well as CR1-medi
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To validate the identified phosphorylation
2023-03-22
To validate the identified phosphorylation sites in the mouse heart, we analyzed HEK 293T D-NMAPPD sale transfected with Adrb1 based on the hypothesis that protein residues phosphorylated both in vivo and in vitro are more likely to be physiologically relevant. All of the phosphorylation sites iden
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In terms of the ring
2023-03-22
In terms of the ring B C5′ position, while C5′-F (compound ) was tolerated, C5′-Me (compound ) and C5′-Cl (compound ) substitutions resulted in a loss in potency. However, the C5′-OMe substitution (compound ) resulted in a ∼3-fold increase in potency compared to . Modeling suggested a pseudo hydroge
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The biological characteristics of cancer invasion and metast
2023-03-22
The biological characteristics of cancer invasion and metastasis are mainly attributed to the poor prognosis in cancer. It has been reported that overexpression of Ack1 promoted the migratory and invasive properties of breast cancer avibactam by sustaining expression of epidermal growth factor. In c
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