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br STAR Methods br Acknowledgments We thank Emeritus
2022-08-19
STAR★Methods Acknowledgments We thank Emeritus Professor Chikashi Shimoda and Professor Taro Nakamura of the National BioResource Project/Yeast Genetic Resource Center (NBRP/YGRC) at Osaka City University (Osaka, Japan) for Schizosaccharomyces pombe meiotic cDNA library, yeast plasmids, yeast
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br Significance Cellular heterogeneity for phenotypic
2022-08-19
Significance Cellular heterogeneity for phenotypic features is a key mechanism underlying disease progression and therapeutic resistance, yet its regulation is poorly understood at the molecular level. Our findings demonstrate that endocrine resistance is associated with higher transcriptomic het
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Glycine released from astrocytes as well
2022-08-19
Glycine released from astrocytes as well as neurons is also known as a co-agonist of NMDAR (Roux and Supplisson, 2000). Neuronal glycine in mouse hippocampus might be released from glutamatergic terminals (Muller et al., 2013) that express functional tetracycline hcl receptors (Rodriguez et al., 199
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Several studies have indicated that PLD regulated PA signali
2022-08-19
Several studies have indicated that PLD-regulated PA signaling intersects with Rho-mediated cytoskeletal remodeling to drive mesenchymal-like cellular features, and it is known that Rho signaling has the potential to induce YAP/TAZ nuclear activity. Accordingly, Han et al. (2018) provide evidence th
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However HDACi can also increase the acetylation of other
2022-08-19
However, HDACi can also increase the acetylation of other transcription factors that regulate p65 transcriptional activity. The HDACi-induced activation of p65 can be negated by acetylated STAT1, which can specifically bind to p65 and inhibit its transcriptional activity 81, 82, 83. Interestingly, a
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According to literature RASs V M T S Q
2022-08-19
According to literature, RASs V36M, T54S, Q80K and R155K are considered primary resistance mutations to different PIs. RASs V36M and R155K can reduce susceptibility to recently approved PIs simeprevir, paritaprevir and grazoprevir [18], [31], [32]. T54S is associated to resistance for first-wave tel
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Organisms can adapt to increasing ROS production by up regul
2022-08-19
Organisms can adapt to increasing ROS production by up-regulating antioxidant defences, such as the activities of antioxidant enzymes (Livingstone, 2003). Failure of antioxidant defences to detoxify excess ROS production can lead to significant oxidative damage including enzyme inactivation, protein
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Whilst it has long been
2022-08-19
Whilst it has long been appreciated that Rho-family GTPases are able to signal directly to focal adhesions, it is also becoming increasingly clear that they can achieve this indirectly, through their influence on the extracellular matrix to which the integrins bind. Cdc42 and RhoA have long been kno
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br Molecular mechanisms underpinning GSNOR function
2022-08-19
Molecular mechanisms underpinning GSNOR1 function in the defence response Recently, Arabidopsis GSNOR1 has been shown to govern the extent of S-nitrosylation of two key regulatory proteins, Non-Expresser of Pathogenesis-Related Genes 1 (NPR1) and SA binding protein 3 (SABP3), which are integral t
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Approximately mammalian genes encoding family A or rhodopsin
2022-08-19
Approximately 250 mammalian genes encoding family A (or rhodopsin-like) GPCRs have been cloned (Lee et al., 2001a). As yet, the total number of cloned GPCRs reported in the literature including the secretin and metabotropic glutamate-like families of GPCRs falls short of the projected 616 GPCR-encod
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br Conclusions Beta cell specific expression in human islets
2022-08-19
Conclusions Beta cell-specific expression in human islets of DGCR2, GBF1, GPR44 and SerpinB10 has not previously been described, although the proteins have partly been characterized in other contexts not related to beta TOK-001 or diabetes. DGCR2, GPR44 and SerpinB10 were negative in all other c
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In order to investigate whether this
2022-08-19
In order to investigate whether this off-target activity was related to a particular structural feature of this PD173074 or was characteristic of the series, compounds , and were selected as being matched pairs with compound but with structural variation in terms of the R, R and R groups, respective
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br Introduction The amino acid glycine functions as
2022-08-18
Introduction The amino CCT245737 glycine functions as a neurotransmitter in the vertebrate central nervous system: as an inhibitory neurotransmitter and as a co-agonist of the NMDA-subtype of excitatory glutamatergic receptors (Eulenburg et al., 2005). Under a current hypothesis that schizophren
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br Significant efforts are currently focused on non dopamine
2022-08-18
Significant efforts are currently focused on non-dopaminergic strategies to address the unmet medical needs in schizophrenia, and targeting -methyl--aspartate (NMDA) D-Luciferin sodium salt hypofunction has garnered a great deal of attention., , Elevation of synaptic glycine levels near NMDA-con
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A major hurdle in purifying a
2022-08-18
A major hurdle in purifying a membrane protein is finding a detergent that can preserve the protein, after releasing it from a given membrane, in a stable and non-aggregated state during purification steps [18,50]. The ability of various detergents used to solubilize and purify membrane proteins has
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