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Conflict of Interest The authors
2022-08-04
Conflict of Interest: The authors have no conflicts of interest to declare. Acknowledgments Understanding Pulmonary Remodeling The effects of serotonin (5-hydroxytryptamine, 5-HT) class 2 receptors (5-HT2) on airway function and remodeling in respiratory disorders are unclear. Using murine pr
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5224 Biochemical assays have provided evidence that prolonge
2022-08-04
Biochemical assays have provided evidence that prolonged exposure to GPR35 agonists can induce GPR35 internalization [2], [4], [11], [13]. Our finding that neuronal excitability decreased regardless of whether the slices were superfused for a few minutes or incubated for a few hours with GPR35 agoni
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To help resolve the question of simple binding versus transp
2022-08-03
To help resolve the question of simple binding versus transport, we reasoned that if quercetin is transported by GLUT1, we should be able to block its uptake by other GLUT1 inhibitors. We initially investigated the effects of two newly identified GLUT1 inhibitors, BAY-876 and WZB-117. WZB-117 was fi
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A number of models have been proposed in order
2022-08-03
A number of models have been proposed in order to explain the mechanisms of protein transport through nuclear pore complexes. One theory is that the transport is mediated by specific peptide signals known as NLSs. The classical NLSs are short sequences containing a high proportion of the positively
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As early as glucagon was shown to increase
2022-08-03
As early as 1957, glucagon was shown to increase 96 4 expenditure in rodents in both pair-feeding studies and through directly increasing oxygen consumption [23], [24]. This has more recently been confirmed in man, through indirect calorimetry during glucagon infusions [25], [26], [27]. This contra
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br Disclosure br Ghrelin System The existence of
2022-08-03
Disclosure Ghrelin System The existence of the ghrelin system has been demonstrated in many species through a variety of biochemical, anatomical, and genetic studies. It is a complex and intricate regulatory system comprised of several peptides, including mature ghrelin and its derivative des-
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However protection against kainic acid induced injury was no
2022-08-03
However, protection against kainic acid-induced injury was not found by Lin et al. (2003) in the rats with AAV-GAL vector-mediated galanin overexpression, even though these animals, as mentioned earlier, exhibited attenuated of seizure severity. Although the reason for the controversy between the st
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The stability of the i motif at the neutral pH
2022-08-03
The stability of the i-motif at the neutral pH has been analyzed in our previous paper [31] by tracking the rmsd changes in unbiased calculations. Fig. 7 presents, just to confirm the conclusions drawn in [12], the changes in distances between atoms forming hydrogen bonds within the i-motif structur
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br The signal of ferroptosis ROS generated by extracellular
2022-08-03
The signal of ferroptosis ROS generated by extracellular or intracellular stimuli play a fundamental role in cell and tissue injury in a variety of disease states [47]. Ferroptosis is generally considered as a type of ROS-dependent regulated necrosis [48]. Intracellular iron accumulation and lipi
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annexin v synthesis However at variance with the well studie
2022-08-03
However, at variance with the well-studied R form of FBP1 which is flat, the R state of FBP2 is diametrically different, with a perpendicular orientation of the upper and lower dimers (Barciszewski et al., 2016). The cruciform-like R state of FBP2 is stabilized by a unique hydrophobic motif called ‘
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ADAM has two alternative splicing forms
2022-08-03
ADAM12 has two alternative splicing forms, a membrane-anchored long form (ADAM12-L) and a secreted short form (ADAM12-S). Both the long and short forms have metalloproteinase, disintegrin, cysteine-rich, and epidermal growth factor-like domains and can shed pro-heparin binding-epidermal growth facto
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Over of all melanomas have activating BRAF mutations
2022-08-03
Over 50% of all melanomas have activating BRAF mutations [29] and inhibition of the Ras/Raf/MEK/ERK signaling pathways is one of the most promising treatments for malignant melanoma [30]. However, studies using BRAF inhibitors have identified various feedback mechanisms to activate BRAF pathway in m
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Glyoxalase I inhibitor Finally the optimized leads and were
2022-08-03
Finally, the optimized leads (−)- and (−)- were tested in rat model of CIPN (3 and 30 mg/kg, po, qd, administered for 7 days) and the results have been shown in . Under acute set up, after single oral administration at 30 mg/kg, both the compounds exerted significant improvement of the NP condition
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br Conclusions and perspectives br Acknowledgements This
2022-08-03
Conclusions and perspectives Acknowledgements This work was supported by the National Natural Science Foundation of China (Grant Nos. 21802173, 21405182 and 21773315), the Natural Science Foundation of Guangdong Province (Grant Nos. 2018A030310301, 201710010019 and 2014A030313232, 201804020025
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Chicoric acid CA is a di
2022-08-03
Chicoric MRT67307 HCl (CA) is a di-acylated hydroxycinnamoyl tartaric acid ester [12] found in a variety of plant species, especially within the Astereceae family [13]. Of interest for this study, Sonchus oleraceus and Bidens pilosa plants, from Astereceae family, were used. Both S. oleraceus and B
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