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One of pathogenesis of COPD is oxidant antioxidant imbalance
2022-01-18
One of pathogenesis of COPD is oxidant/antioxidant imbalance. Indeed, it is well known that chronic tobacco smoking is a major risk factor for the development of COPD, and a defect in the detoxification of reactive species produced by cigarette smoke may predispose smokers to airflow obstruction and
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During embryogenesis the expression of
2022-01-18
During embryogenesis, the expression of zGpr84 was found higher at the cleavage stage and decreased at both blastula and gastrula stages. It indicates that maternal zGpr84 transcripts are present at the cleavage and blastula stages, since zygotic transcripts are not produced before the gastrula stag
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Cichlasoma dimerus as most teleost fish species present neur
2022-01-18
Cichlasoma dimerus, as most teleost fish species, present neurons expressing GnRH3 (Pandolfi et al., 2005). As in most Methoxyresorufin synthesis species, the neurons expressing GnRH3 are mainly located in the NOR, although few neurons were detected in the olfactory bulb, ventral telencephalon and
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To shed more light on the
2022-01-18
To shed more light on the binding of benzophenanthridine to GlyT1, we studied how the replacement of certain residues around the sanguinarine sensitive cysteine 475 previously identified (Jursky et al., 2012) affects GlyT1 inhibition of by these alkaloids. Based on these results we propose a putativ
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Acute effects of FZ were not altered in GluR A
2022-01-18
Acute effects of FZ were not altered in GluR-A−/− mice, thus providing a solid basis for comparing the effects of repeated drug administration. In addition, GluR-A subunit deficiency did not affect the basal behavior of saline-treated animals, despite the GluR-A−/− mice having been described as hype
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L-817,818 How do myofibroblast sources compare between
2022-01-18
How do myofibroblast sources compare between bone marrow and other organs? Perivascular L-817,818 with MSC properties significantly contribute to fibrosis in muscle, fat, skin, heart, kidney, lung, and liver (reviewed in Iwayama et al., 2015) and activate Gli1 in many of these organs (Kramann et al
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In order to test the influence of the initial
2022-01-18
In order to test the influence of the initial depolarization, experiments were performed, where the degree of chloride substitution was varied, either by adding n-Ringer to Oseltamivir incubated in a sucrose Ringer or by suspending the cells directly in Ringers identical to the final composition in
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ACET receptor The modulation of the activity
2022-01-18
The modulation of the activity of the Gardos channel by the chemokines IL-8 and RANTES was observed in the Duffy-positive but not in the Duffy-negative SSRBCs. This finding is consistent with the previous observation on normal red blood ACET receptor (AARBCs) described by Rivera et al. [10]. Altoget
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G quadruplex DNA structures may exist
2022-01-18
G-quadruplex DNA structures may exist in either positive or negative strand of a promoter to regulate gene expression. The positive strand of the HOXC10 promoter is overall C-rich in the 1000 bp upstream of the TSS (36.6% of C versus 24.1% of G) and contains many C-runs; thus, G-quadruplex structure
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DLPC synthesis br Materials and methods br Results br Discus
2022-01-18
Materials and methods Results Discussion It is known that MAPKs and Akt signaling can regulate cell migration [[24], [25], [26]]. In this study we found that dTAT-WKYMVm stimulates ERK, p38 and Akt phosphorylation in naïve CD4 T cell (Fig. 3A). However their activation did not affect naïve
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The apparent lack of effect of Fas deficiency
2022-01-18
The apparent lack of effect of Fas deficiency on MAV-1 replication in infected mice could be due to immunoevasion by virus inhibition of Fas activation. If that were the case, Fas deficiency would likely have minimal additional effect. HAdV infection triggers Fas internalization from the cell membra
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br Chemistry All the title
2022-01-18
Chemistry All the title molecules were generally synthesized using the procedures shown in Scheme 1, Scheme 2, Scheme 3 [17,18,23,24]. The key 2-chloropyrimidine intermediate 11 was prepared according to our previously reported method via subsequent formylation, reduction, and nucleophilic substi
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br GSNOR activity and functions The identification of the en
2022-01-17
GSNOR activity and functions The identification of the enzyme responsible for GSNO decomposition dates back to 1998, when Jensen and colleagues described an NAD(P)H-dependent GSNO catabolizing activity in cytosolic fractions obtained from rat liver [16]. Upon purification, they identified this en
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br GSK Glycogen synthase kinase GSK is a ubiquitous
2022-01-17
GSK-3 Glycogen synthase kinase-3 (GSK-3) is a ubiquitous serine/threonine kinase that is involved in multiple signaling pathways that are crucial for cellular metabolism and proliferation (Doble and Woodgett, 2003, Frame and Cohen, 2001, Grimes and Jope, 2001, Woodgett, 1990). GSK-3 is known to d
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The neurobiological mechanisms underlying DHK induced
2022-01-17
The neurobiological mechanisms underlying DHK-induced NOR learning and memory impairments remain unclear. Accumulated evidence shows that astrocyte-neuron lactate shuttle is of crucial important in synaptic plasticity and memory formation, and regulation of neuronal gene expression related to synapt
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