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In this review we will highlight
2021-11-29
In this review we will highlight how the functional impact of GABA receptors activation in thalamic neurons far exceeds the traditional “shunting” effect and shapes the whole thalamic network excitability. We will show how GABA released during either tonic or burst firing of GABAergic thalamic neuro
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The primary cancer lesion was mostly
2021-11-29
The primary cancer lesion was mostly in the uterus and adnexa, followed by the gastrointestinal tract, brain, blood, and kidney and Apocynin (Fig. 2A). Histopathological findings indicated that most cancers were adenocarcinomas, followed by squamous cell carcinomas, glioblastomas, malignant lymphoma
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br Effects of norepinephrine on HIV infection The
2021-11-29
Effects of norepinephrine on HIV infection The few in vitro studies specifically examining the effects of norepinephrine on HIV infection suggest that this catecholamine can influence the HIV replication process, although the precise mechanism is unclear. Cole and colleagues found concentrations
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TRRAP participates in embryonic development as demonstrated
2021-11-29
TRRAP participates in embryonic development, as demonstrated by its binding with proteins regulating the Notch signaling pathway in fruit fly, the Ras signaling pathway in C. elegans, or the Wnt signaling pathway in 293T cells. Therefore we suspect that TRRAP variants, more especially those falling
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br Regulation of HO expression under conditions
2021-11-29
Regulation of HO-1 expression under conditions of ischemic cardiac damage Heart is a vital organ with high metabolic demand, rich in mitochondria and it is very vulnerable to oxidative damage [85]. Disruption in coronary blood flow following MI leads to hypoxia (a reduction in the amount of avail
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We report herein an electrochemical analysis of the interact
2021-11-29
We report herein an electrochemical analysis of the interaction between L1 and sGC, where conventional solution phase voltammetry is combined with a novel technique, the voltammetry of microparticles (VMP), in order to obtain mechanistic information on the deactivation of sGC by L1. The VMP is a sol
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Abnormal expression and higher activity of GLO I
2021-11-29
Abnormal expression and higher activity of GLO I have been detected more in various tumor Capecitabine than in normal cell samples., , , , , , , Among cancer cell lines, lung carcinoma cells frequently showed higher GLO1 activity. Human NSCLC cell line NCI-H522 cells possess high activity and expr
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br Materials and Methods br Results All of the studied
2021-11-29
Materials and Methods Results All of the studied transporter genes were expressed at detectable levels in all the analyzed samples at mRNA level by means of applied rt-PCR method (CTlowest Cisplatin was observed for ABCC4, ABCC1, ABCG2, SLC22A3, and SLC22A18 (less than 10% of mean expression
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Finally it is possible that the increase
2021-11-29
Finally, it is possible that the increase in the number of EAAT-3-labelled cells in the DG at PD 60, when compared with the control and experimental animals at PD 14, is associated with natural changes in the number of neurons present during the postnatal development of the hippocampus (41, 42) and,
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There are also data showing potential beneficial effects of
2021-11-26
There are also data showing potential beneficial effects of SGLT2i on non-alcoholic fatty liver disease (NAFLD) [[14], [15], [16], [17]], a hepatic manifestation of the metabolic syndrome that has been linked to type 2 diabetes mellitus (T2DM) development and increased cardiovascular (CV) as well as
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br Experimental br Results br Discussion
2021-11-26
Experimental Results Discussion The use of Dex-BSA asa membrane-limited glucocorticoid has been met with some skepticism, mainly for its assumed instability. Here we provide conclusive evidence that Dex-BSA is stable in solution over an extended period of time and at high temperature (i.e.,
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br Discussion and concluding remarks FPR is considered to
2021-11-26
Discussion and concluding remarks FPR1 is considered to be a promising drug target for treating inflammatory and immunological diseases. Thus, natural compounds that could block and/or regulate FPR1 activity may be an important source of novel therapeutics for modulating inflammatory processes. H
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Cell stiffness is determined by the cytoskeleton an intracel
2021-11-26
Cell stiffness is determined by the cytoskeleton, an intracellular polymeric network consisting of Endomorphin-1 filaments, microtubules, intermediate filaments, and crosslinking proteins [38]. Low cell stiffness has been correlated with reduced formation of well-defined F-actin filaments or bundle
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The anti platelet functions of ZGR were
2021-11-26
The anti-platelet functions of ZGR were confirmed by the mechanistic studies such as the activation of PKC, intracellular Ca2+ mobilization, and the expressions of P-selectin and PAC-1. Further, rivaroxaban prolonged the generation of thrombin and reduced the thrombin burst produced in the propagati
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Furthermore the immunoassays described in our study showed
2021-11-26
Furthermore, the immunoassays described in our study showed excellent concordance of more than 93.33% with the LAg-Avidity EIA (Table 2). Using a panel of samples obtained from HIV-1 seroconverters over the course of up to 602 days post-infection, the gp41 peptide-based MP3 or MP4 assay identified s
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