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Importantly bioelectric circuits in tissues Fig
2021-11-18
(4) Importantly, bioelectric circuits in tissues (Fig. 2A) have a capacity to store long-term patterning information. An example is planarian anterior-posterior patterning: during regeneration, each fragment cut from a worm needs to build a head and tail at their correct ends. This process is regula
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br Short Communication Lactococcus lactis is
2021-11-18
Short Communication Lactococcus lactis is traditionally used as a starter culture in the production of fermented dairy food products, such as cheese, sour cream, and buttermilk (Cavanagh et al., 2015). Two main pathways of lactose uptake and metabolism have been described for L. lactis. In the fi
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Adipocytes play diverse roles in energy homeostasis
2021-11-18
Adipocytes play diverse roles in energy homeostasis by controlling energy consumption [8] and function as a source of proteins and cytokines, which mediate numerous physiological functions [9]. Excessive accumulation of adipocytes, as well as an increase in either their size or number, causes obesit
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The more important effect of pitolisant is related to
2021-11-18
The more important effect of pitolisant is related to its wake-promoting and arousal activities as a result of enhanced src inhibitor release in animal models (Ligneau, Perrin, et al., 2007). Moreover, its potential in the treatment of severe excessive daytime sleepiness (EDS) in narcoleptic teenag
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br Introduction Topological hedgehogs keep generating intere
2021-11-18
Introduction Topological hedgehogs keep generating interest in point-set topology as they are a rich source of counterexamples and applications (for a comprehensive survey on topological hedgehogs we refer to [1]; see also [9]). They may be described as a set of spines identified at a single poin
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trans-AUCB Vicenti et al assessed the prevalence of
2021-11-18
Vicenti et al. [38] assessed the prevalence of HCV NS3/4A PI resistance mutations in HCV genotype 1-infected PI-naïve individuals, including 66 subjects coinfected with HCV/HIV. They found that 19.3% of isolates have at least one mutation related to PI resistance, and the HCV PI resistance mutations
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ampa receptor Several studies have reported that the genotyp
2021-11-18
Several studies have reported that the genotype and allele frequencies of S267F vary considerably between different study groups and geographical regions (Ezzikouri et al., 2017, Hu et al., 2016, Lee et al., 2017, Li et al., 2014, Pan et al., 2011, Peng et al., 2015, Yang et al., 2016, Zhang et al.,
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Interestingly interactions between Smad and RhoA the other
2021-11-18
Interestingly, interactions between Smad3 and RhoA, the other small GTPase which is highly homologous to RhoB [9], could not be observed suggesting that the Smad3/RhoB interactions require amino T7 High Yield RNA Synthesis residues that are unique to RhoB. Combined with our previous observation that
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Furthermore the higher expression levels of DNMT seemed to b
2021-11-18
Furthermore, the higher expression levels of DNMT1 seemed to be responsible for the elevated levels of methylation in the GSTP1 and TXNRD2 promoters in HMC. In the DNA methyltransferase family, the functions of DNMT1 and DNMT3, including 3a and 3b, were the most ubiquitously expressed in cells. DNMT
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Two genes PATL and RASSF whose relationship to HIV
2021-11-18
Two genes (PATL2 and RASSF1), whose relationship to HIV infection had not previously been reported, were identified in this study. Although PATL2 and RASSF1 have been implicated in cell division and tumor suppression, respectively (Scheller et al., 2007, Rather et al., 2014, Liu et al., 2002), their
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br Materials and methods br
2021-11-18
Materials and methods Results Discussion To understand the molecular basis for how ghrelin secretion is regulated at the cellular level, we identified the full repertoire of 7TM receptors and G proteins in gastric ghrelin Immunology Compound Library and functionally characterized the majori
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Lactate as administered in these models is
2021-11-18
Lactate as administered in these models is metabolized rapidly and it appears that transient engagement of GPR81 with lactate serum concentrations in the range of moderate exercise physiology, as measured here at 3–4 mmol/L, are sufficient to suppress tissue macrophage NF-κB activation in our models
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To combat the detrimental effects of neuropathological condi
2021-11-18
To combat the detrimental effects of neuropathological conditions, additional therapeutic interventions that either dampen chronic neuroinflammation or attenuate reductions in hippocampal neurogenesis are critically needed. The cannabinoid system has already been shown to rescue impaired neurogenesi
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To get a broader view of the
2021-11-17
To get a broader view of the interplay between glycolysis and Hippo signaling, we tested the involvement of YAP1 in the regulation of C-MYC and GLUT1 expression. We were able to detect a YAP1-TEAD1 interaction in the nuclear fraction of Jurkat Hydroxyurea and confirm the inhibition of this interact
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br Materials and methods br Conflicts of interest
2021-11-17
Materials and methods Conflicts of interest Some of the peptidomimetic compounds in this work are the subject of the patent application “Peptidomimetics for Imaging the Ghrelin Receptor”, WO/2016/191865 A1, December 8th, 2016. Acknowledgements Special thanks go to Rebecca McGirr (Lawson He
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