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In this review we will
2021-11-01
In this review we will highlight how the functional impact of GABA receptors activation in thalamic neurons far exceeds the traditional “shunting” effect and shapes the whole thalamic network excitability. We will show how GABA released during either tonic or burst firing of GABAergic thalamic neuro
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br Introduction The term autophagy
2021-11-01
Introduction The term “autophagy” was coined by Christian de Duve in 1963 to describe the process of removing and degrading intracellular components such as unused proteins and damaged organelles through lysosomes [1,2]. Autophagy has been divided into three main types, namely, macroautophagy, mi
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br Materials methods br Results FAS c AA AG
2021-11-01
Materials & methods Results FAS c.-671AA, AG and GG genotypes and A and G Phleomycin frequencies were similar in both patients with FMF and healthy control groups, and no significant difference was found (P>0.05, Table 1). The frequency of TC genotype in FASLG in the healthy controls was sign
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The primary or in transit
2021-11-01
The primary or in-transit site of metastasis for many cancers, including melanoma, are nearby sentinel lymph nodes (LNs) [6]. As such, sentinel LN biopsy is a common procedure to diagnose and stage melanoma progression [7,8]. Sentinel LNs are often the primary site of metastasis due to tumor cell-st
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FXa is a vitamin K dependent
2021-11-01
FXa is a vitamin K-dependent serine protease consisting of two chains linked by a disulfide bridge. The heavy chain contains 303 endothelin receptor and the light chain has 139 amino acids. The catalytic triad comprised of Ser195, His57, and Asp102 exhibits the trypsin-like β-barrel structure [12].
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br Introduction The coronary vasculature is required for
2021-11-01
Introduction The coronary vasculature is required for supplying oxygenated blood to the cardiac muscle. Proper coronary blood circulation is essential for embryonic and adult cardiac tissue homeostasis. Defects associated with the coronary function leads to myocardial ischemia, infarction, and he
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In our substudy patients carrying the Ile Val or Val
2021-11-01
In our substudy, patients carrying the Ile/Val or Val/Val genotypes had significantly worse DFS compared to patients carrying the Ile/Ile genotype, after adjustment for potential confounders. Two previous studies examining the association between HER2 Ile655Val polymorphism and trastuzumab response
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The synthesis of target compound RS C is illustrated as
2021-11-01
The synthesis of target compound (RS)-C02 is illustrated as Scheme 2. Compound (RS)-3 was synthesized as reported procedures [40] and then reacted with ethyl piperidine-4-carboxylate to yield (RS)-C01, which subsequently was converted to target molecule (RS)-C02 by performing a nucleophilic substitu
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Assays can perform differently by genotype and
2021-11-01
Assays can perform differently by WM-1119 and under-quantification of HCV GTs has been seen with HCV assays [8], [9], [10], [11]. Under-quantification of GT4 has been reported in some early studies of the VERIS Assay [7], [12] where a bias greater than −0.5 log10IU/mL was seen. In two more recent e
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Whereas Sororin is dispensable in the absence of Wapl
2021-10-29
Whereas Sororin is dispensable in the absence of Wapl [14], overexpressed Haspin only partly supports cohesion in Sororin-depleted cells. Thus, although Haspin and Sororin have functional similarities, they are not fully redundant at the centromere. Haspin may have a mitosis-specific role in maintai
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It is an open question if
2021-10-29
It is an open question if these in vitro findings have implications for the use of sGC activators in the in vivo situation and in patients. Assuming that incorporation in de novo synthesised enzyme occurs during therapy, one might speculate that the duration of drug administration has an influence o
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Interestingly the rabbit cornea exhibited a
2021-10-29
Interestingly, the rabbit cornea exhibited a more than two-fold higher level of total GST activity compared with that of the porcine cornea, whereas their levels of GSTO1‐1 and GSTP1‐1 activity were similar (Fig. 4). Because members of the GST Alpha, Mu, Pi and Omega anderson kpt primarily utilize
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br Since viral infections result in
2021-10-29
Since viral infections result in polarization of naïve CD4 T cells into both Th1 and Tfh subsets (although to variable degrees depending on the nature of the pathogen), a lot of effort has been devolved to the question of whether type I IFNs play a role in CD4+ T cell polarization. In vitro studie
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Moreover there is a third possible GnRH agonist target the
2021-10-29
Moreover, there is a third possible GnRH agonist target – the endometrium. The human endometrium has been shown to express high levels of both GnRH and GnRH receptors (Maggi et al., 2016), and GnRH agonists affect the function of the urokinase-type plasminogen activator/plasminogen activator inhibit
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br Acknowledgments This work was
2021-10-29
Acknowledgments This work was supported by the Russian Foundation for Basic Research [grant number 16-04-00205], The Russian Science Foundation [grant number 16-15-00235], Czech Academy of Sciences [grant number RVO 61388963], and the Technology Agency of the Czech Republic [grant number TE010200
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