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The lungs dissected from week mice were cut
2019-10-10
The lungs dissected from 4–5-week mice were cut into small pieces and then immersed in Dulbecco\'s modified Eagle\'s medium (Invitrogen, Carlsbad, CA) containing collagenase II (2 mg/ml), trypsin (2.5 mg/ml), Dnase I (2 mg/ml), penicillin (100 U/ml), and streptomycin (100 μg/ml) for 12 hours at 37
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Autophagy alterations are frequently reported as one
2019-10-10
Autophagy alterations are frequently reported as one of the pathological mechanisms contributing to neurodegenerative diseases, due to incomplete removal of protein prostaglandin receptor in the brain [30,41]. It was over a decade ago when mutations in PARK8 encoding for the LRRK2 protein were desc
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We thank Dr Hongqiang Qin at Dalian Institute of
2019-10-10
We thank Dr. Hongqiang Qin at Dalian Institute of Chemical Physics, Chinese Academy of Sciences for technical assistance in mass-spectrometric analysis. We thank Prof. Quentin Liu at Dalian Medical University and Prof. Qiang Shen at M.D. Anderson Cancer Center for helpful discussion and comments. Dr
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Conversely to the reduction in restraint evoked HR increase
2019-10-10
Conversely to the reduction in restraint-evoked HR increase following the blockade of CRF receptors, Nijsen et al. [28] demonstrated that BNST treatment with a nonselective CRF Asiatic acid pathway antagonist enhanced the tachycardia evoked by contextual fear conditioning. Taken together, these res
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Koumine br Experimental br Declaration of interest br
2019-10-10
Experimental Declaration of interest Introduction Material and methods Results and discussion Conclusion By screening the NMR Koumine library an initial hit was found for an inhibitor of the PPI between the α-β subunits of CK2 with an IC50 of 900 μM. This compound was modified and
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br Materials and methods br Results br
2019-10-10
Materials and methods Results Discussion Taken together with our previous report, our current data demonstrate induction of Chk in monocytes by IL-3, IL-4, IL-13, and GM-CSF ((Musso et al., 1994) and Fig. 1, Fig. 2, Fig. 3, Fig. 4). Chk lipoxygenase inhibitor is also inducible by stem cell
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The COMT gene is involved in numerous psychological and phys
2019-10-09
The COMT gene is involved in numerous psychological and physiologic processes, including modulation of pain. Polymorphisms in this gene have also been associated with many painful conditions, including pain sensitivity in children. Bivariate analysis demonstrated that individuals with heterozygous C
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br EphB as a therapeutic target in cancer Eph receptors
2019-10-09
EphB4 as a therapeutic target in cancer Eph receptors and ephrins are promising new therapeutic targets in cancer. Various strategies have been employed to evaluate the interference of tumor-promoting effects or the enhancement of tumor suppressive effects. The inhibition of the Eph-ephrin system
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Importantly our in vivo data
2019-10-09
Importantly, our in vivo data fit to the in vitro data, further confirming the synergistic effect of XJD and gefitinib on the inhibition of lung cancer and the regulation of SP1, HOTAIR, and EP4 CW069 levels. The doses of XJD used were based on our previous in vivo study (Zhao et al., 2016). We bel
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Another important new result that has expanded the range
2019-10-09
Another important new result that has expanded the range of functions of iPLA2-VIA in physiology and pathophysiology is its implication in macrophage polarization under stimulation conditions. Ashley et al. [129] described in peritoneal macrophages from Pla2g6−/− mice that the absence of iPLA2-VIA f
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br Halogenases Enzymatic C H activation
2019-10-09
Halogenases Enzymatic C–H activation leading to halogenation is another emerging area in biocatalysis [55,56]. Incorporation of halogen atoms during medicinal chemistry eff ;orts is a well-established practice, presenting an effective means to control the molecule’s bioactivity and physicochemical
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Introduction Enzymes have higher selectivity specificity
2019-10-09
Introduction Enzymes have higher selectivity, specificity and efficiency than chemical catalysts. Due to their properties and their green chemistry, biocatalysts are widely used in food, textile and pharmaceutical industry [1], [2]. A high efficient biocatalyst for industrial applications must be s
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ELUXA HM EMSI is an ongoing pivotal Phase II global
2019-10-09
ELUXA 1 (HM-EMSI-202) is an ongoing pivotal Phase II global clinical trial, designed to further investigate the efficacy and safety of Olmutinib in patients T790M-positive NSCLC with acquired resistance after first-line EGFR TKIs. Primary endpoint is ORR according to RECIST 1.1, while secondary endp
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Increased levels of PCNA monoubiquitination by UbL
2019-10-09
Increased levels of PCNA monoubiquitination by UbL73P expression in a damage-independent manner mimics the phenotype observed for USP1 knockdown (Huang et al., 2006, Jones et al., 2012). USP1 is the only DUB to date shown to remove ubiquitin from PCNA in vivo. This finding reveals the highly dynami
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4μ8C br Experimental methods br Results and discussion br
2019-10-09
Experimental methods Results and discussion Conclusion Rational design of highly selective fluorescent probes to detect G-quadruplexes is of profound importance for basic research. On this basis, we designed and synthesized a series of N-alkylated styrylquinolinium dyes Ls-1, Ls-2 and Ls-3.
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