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To extend these toxicity minimization strategies to D
2019-07-25
To extend these toxicity minimization strategies to 3D tissues, a more complicated mass transfer model is necessary to account diffusion in the interstitial space, as well as transport across cell membranes. Until recently, tissue mass transport in cryobiology was modeled using classic spatially dep
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Partial suppression of the cot ts phenotype by deletion of
2019-07-25
Partial suppression of the cot-1 (ts) phenotype by deletion of gul-1 has been well documented (Seiler et al., 2006). This is now also very clearly evident in the transcriptional profile of the various strains (Fig. 2). Furthermore, the comparative analysis of the single and double mutants revealed,
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Given that dimethylamine substitution was tolerated as in
2019-07-25
Given that dimethylamine substitution was tolerated as in SR106447 (), we investigated RK-33 amine substitutions as replacements for the -butyl group (). Cyclic amines (SR19880, 19882) or simple mono-substituted anilines (SR20037) were not active, nor was an acetylated version (SR20039). The slight
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The Kaempferia parviflora extract met the
2019-07-25
The Kaempferia parviflora extract met the criteria for a non-competitive interaction with CYP1A1 based on the decrease of Vmax and unchanged Km. The high Ki value and low IC50, as well as the high Km value was indicative of the weakness of the interaction between the Kaempferia parviflora extract an
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In the phase I AURA trial patients with EGFR activating
2019-07-25
In the phase I AURA trial, patients with EGFR activating mutations and centrally confirmed tumor and/or plasma genotyping (BEAMing) T790M result were enrolled. Among 216 patients with both plasma and tissue genotyping results, the concordance rate was 82% for Bleomycin Sulfate 19 deletions, 86% for
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br Analytical improvements Since our
2019-07-25
Analytical improvements Since our review of “Oxysterol Metabolomes” in 2011 [7], there have been a number of improvements in analytical methods for the analysis of oxysterols and related compounds. McDonald and colleagues in Dallas have refined their LC-MS methods which are now applicable for ana
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CX5461 br Cytokine profile in MPN
2019-07-24
Cytokine profile in MPN: Results from experimental investigation Cytokines are small molecules constituted by proteins or glycoproteins, which regulate the immune cell function and the immune system. They are secreted mainly by immune CX5461 but also by other cells such as epithelial cells in res
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We have previously disclosed the discovery of a
2019-07-24
We have previously disclosed the discovery of a 7-azaindole-3-acetic SL-327 chemical CRTh2 antagonist chemotype 1 from HTS and its subsequent optimization to give 2 as a potent and orally bioavailable inhibitor of eosinophil shape change (SC) in human whole blood. Subsequent to disclosure of that w
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Although the phase I clinical trial
2019-07-24
Although the phase I clinical trial of LMB was unsuccessful, the detailed review of this trial only mentions some malaise and anorexia as side effects, which are common for most effective chemotherapeutic drugs. These side effects may diminish if lower doses are administered. In view of the novel CR
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XMU-MP-1 Previous studies have shown the harmful
2019-07-24
Previous studies have shown the harmful effects of NEFA on ovarian functionality, such as inhibition of bovine granulosa cell survival and proliferation, steroidogenesis, and follicular development and alteration in oocyte development [36,45,46]. Therefore, the higher levels of NEFA found in the fol
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Notochord is a transient structure differentiating at early
2019-07-24
Notochord is a transient structure differentiating at early stage during embryogenesis that is at the origin of vertebral bodies in all vertebrates. In zebrafish, it is composed of vacuolated equol surrounded by a unique ECM structure improperly called notochordal BM. As in chicken and amphibians,
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The reduction of the calcium response to AVP
2019-07-24
The reduction of the calcium response to AVP could be also due to a PKA-mediated effect of desensitization of IP3R, as described in rat megakaryocytes [41]. Furthermore, PKA activation inhibits intracellular Ca release in mouse pancreatic acinar cells [42] or in rat cerebellum [43]. The phosphorylat
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Elacridar Besides chemopreventive effects against oxidative
2019-07-24
Besides chemopreventive effects against oxidative DNA damage we evaluated the protective effects of the three Hypericum sp. and isolated compounds against alkylating DNA damage induced by MMS in HT29 cells. Human exposure to alkylating agents, from different sources, occurs in a continuous way and i
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In this study we examined a
2019-07-24
In this study, we examined a possible association between the 19-bp cyproheptadine hcl and the 9-bp repeat in the DHFR gene and the risk of spina bifida in 121 mothers of a spina bifida affected child, 292 control women, 109 spina bifida patients and 234 pediatric controls using a case-control desig
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DGAT is specifically responsible for endogenous synthesis
2019-07-24
DGAT2 is specifically responsible for endogenous synthesis of TAGs which are then packed into cytosolic LDs in the cytosol for storage and luminal apolipoprotein B (apoB)-containing LDs in the ER lumen destined for VLDL secretion [122,127]. DGAT2 can also synthesize TAG using exogenous FAs and suppo
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