• br Conclusion br Acknowledgements br Introduction In

  2019-10-11

  

  Conclusion Acknowledgements Introduction In recent years, fast progress has been made toward using the supercritical technology in industrial separation processes. Apart from a green extraction process that replaces organic solvents, applications involving supercritical fluids include super

• The acids applied in this study

  2019-10-10

  

  The acids applied in this study are commonly used in dental practice. Phosphoric ML-090 is an oxyacid used regularly for adhesion of resin composites. Enamel phosphoric acid etching can dissolve and demineralize the inorganic [Ca10(PO4)6(OH)2] matrix, creating micro pores and microgrooves to improve

• Caspase-2, human recombinant proteinase For the SAR optimiz

  2019-10-10

  

  For the SAR optimization of the right hand side, it was decided to explore the inclusion of the key carboxylic Caspase-2, human recombinant proteinase moiety present in the original DGAT-1 inhibitors from . Analogs were constructed by the synthetic routes outlined in , . In , the methylene-oxy link

• Introduction Formate dehydrogenase enzymes FDHs are a group

  2019-10-10

  

  Introduction Formate dehydrogenase enzymes (FDHs) are a group of heterogeneous proteins that catalyse the reversible formate () oxidation to carbon dioxide () (Eq. (1)). These enzymes are classified in two families, one gathering the enzymes that hold no redox-active centres and another that includ

• The lungs dissected from week mice were cut

  2019-10-10

  

  The lungs dissected from 4–5-week mice were cut into small pieces and then immersed in Dulbecco\'s modified Eagle\'s medium (Invitrogen, Carlsbad, CA) containing collagenase II (2 mg/ml), trypsin (2.5 mg/ml), Dnase I (2 mg/ml), penicillin (100 U/ml), and streptomycin (100 μg/ml) for 12 hours at 37

• Autophagy alterations are frequently reported as one

  2019-10-10

  

  Autophagy alterations are frequently reported as one of the pathological mechanisms contributing to neurodegenerative diseases, due to incomplete removal of protein prostaglandin receptor in the brain [30,41]. It was over a decade ago when mutations in PARK8 encoding for the LRRK2 protein were desc

• We thank Dr Hongqiang Qin at Dalian Institute of

  2019-10-10

  

  We thank Dr. Hongqiang Qin at Dalian Institute of Chemical Physics, Chinese Academy of Sciences for technical assistance in mass-spectrometric analysis. We thank Prof. Quentin Liu at Dalian Medical University and Prof. Qiang Shen at M.D. Anderson Cancer Center for helpful discussion and comments. Dr

• Conversely to the reduction in restraint evoked HR increase

  2019-10-10

  

  Conversely to the reduction in restraint-evoked HR increase following the blockade of CRF receptors, Nijsen et al. [28] demonstrated that BNST treatment with a nonselective CRF Asiatic acid pathway antagonist enhanced the tachycardia evoked by contextual fear conditioning. Taken together, these res

• Koumine br Experimental br Declaration of interest br

  2019-10-10

  

  Experimental Declaration of interest Introduction Material and methods Results and discussion Conclusion By screening the NMR Koumine library an initial hit was found for an inhibitor of the PPI between the α-β subunits of CK2 with an IC50 of 900 μM. This compound was modified and

• br Materials and methods br Results br

  2019-10-10

  

  Materials and methods Results Discussion Taken together with our previous report, our current data demonstrate induction of Chk in monocytes by IL-3, IL-4, IL-13, and GM-CSF ((Musso et al., 1994) and Fig. 1, Fig. 2, Fig. 3, Fig. 4). Chk lipoxygenase inhibitor is also inducible by stem cell

• The COMT gene is involved in numerous psychological and phys

  2019-10-09

  

  The COMT gene is involved in numerous psychological and physiologic processes, including modulation of pain. Polymorphisms in this gene have also been associated with many painful conditions, including pain sensitivity in children. Bivariate analysis demonstrated that individuals with heterozygous C

• br EphB as a therapeutic target in cancer Eph receptors

  2019-10-09

  

  EphB4 as a therapeutic target in cancer Eph receptors and ephrins are promising new therapeutic targets in cancer. Various strategies have been employed to evaluate the interference of tumor-promoting effects or the enhancement of tumor suppressive effects. The inhibition of the Eph-ephrin system

• Importantly our in vivo data

  2019-10-09

  

  Importantly, our in vivo data fit to the in vitro data, further confirming the synergistic effect of XJD and gefitinib on the inhibition of lung cancer and the regulation of SP1, HOTAIR, and EP4 CW069 levels. The doses of XJD used were based on our previous in vivo study (Zhao et al., 2016). We bel

• Another important new result that has expanded the range

  2019-10-09

  

  Another important new result that has expanded the range of functions of iPLA2-VIA in physiology and pathophysiology is its implication in macrophage polarization under stimulation conditions. Ashley et al. [129] described in peritoneal macrophages from Pla2g6−/− mice that the absence of iPLA2-VIA f

• br Halogenases Enzymatic C H activation

  2019-10-09

  

  Halogenases Enzymatic C–H activation leading to halogenation is another emerging area in biocatalysis [55,56]. Incorporation of halogen atoms during medicinal chemistry eff ;orts is a well-established practice, presenting an effective means to control the molecule’s bioactivity and physicochemical

15909 records 940/1061 page Previous Next First page 上5页 936937938939940 下5页 Last page