• BGJ398 (NVP-BGJ398): Advancing FGFR Signaling Pathway Res...

  2025-09-23

  BGJ398 (NVP-BGJ398) is a potent, selective FGFR inhibitor instrumental for dissecting FGFR-driven mechanisms in cancer and developmental biology. This article explores its applications in oncology, highlights emerging roles in non-malignant systems, and discusses how recent findings on FGFR2 function expand the utility of BGJ398 in experimental research.

• TAK-242 (Resatorvid): Mechanisms and Experimental Guidanc...

  2025-09-22

  Explore the mechanistic basis and experimental considerations for using the selective TLR4 inhibitor TAK-242 (Resatorvid) in neuroinflammation and microglia polarization research. This article provides new insights into its application in neuropsychiatric disorder models and TLR4 signaling pathway modulation.

• Biotin-16-UTP: Enhancing RNA-Protein Interaction Studies ...

  2025-09-19

  Explore the applications of Biotin-16-UTP, a biotin-labeled uridine triphosphate, in advanced RNA detection and purification. This article highlights its distinct advantages in RNA-protein interaction studies and in vitro transcription RNA labeling for molecular biology research.

• VX-765: Selective Caspase-1 Inhibition for Targeted Infla...

  2025-09-18

  VX-765, a potent and selective oral caspase-1 inhibitor, enables rigorous investigation into inflammatory cytokine modulation and pyroptosis inhibition in macrophages. This article explores the mechanistic underpinnings, experimental applications, and emerging research directions for VX-765 in the context of caspase signaling pathways.

• In this study for the first instant we report the

  2025-03-03

  

  In this study, for the first instant we report the characterization, production and in silico structural analysis of BADH1 gene in B. haloduranss SMBPL06 isolated from the salt pan. Moreover, the sequence analysis of betaine aldehyde dehydrogenase from B. haloduranss SMBPL06 displayed several base s

• In young animals the HT A receptor

  2025-03-03

  

  In young animals, the 5-HT2A Mitotic spindle disruptor antagonist ketanserin, at relatively low concentrations, shifted 5-HT concentration-response curves rightward, suggesting a role for 5-HT2A receptors in mediating 5-HT-induced contractions of the ureter. The slopes of the ketanserin Schild plot

• Mangosteen xanthone Finasteride has been shown to be

  2025-03-03

  

  Finasteride has been shown to be a mechanism-based inhibitor of 5AR-2 [9]. Finasteride acts as an alternate substrate for 5AR-2 and is initially bound in an extremely stable enzyme-bound NADP-dihydrofinasteride adduct which is ultimately processed to dihydrofinasteride. The NADP-dihydrofinasteride a

• The exact etiology of BPH is not completely understood

  2025-03-03

  

  The exact etiology of BPH is not completely understood, however this pathology has been associated with elevated Non-apoptotic cell death RSL3 levels of the androgen DHT (10). Thus, a valuable strategy in BHP treatment is the reduction of DHT (10) levels, by inhibiting its biosynthetic production [

• Because the V ATPase inhibitors that have

  2025-03-03

  

  Because the V-ATPase inhibitors that have been employed in these studies (including bafilomycin and concanamycin), are membrane permeant, they inhibit all the V-ATPases in the cell. This is important since it is possible that intracellular V-ATPases, in addition to those present at the plasma membra

• Additionally we used the predicted Cyp a b amino acid

  2025-03-01

  

  Additionally, we used the predicted Cyp19a1b amino SEA0400 sequence from a number of bony fish species to infer their genetic relatedness and found that R. quelen occupies an ancient position within the Siluriformes group. A phylogenetic tree was constructed and it included both full-length and par

• The studies have described that Candida non albicans are con

  2025-03-01

  

  The studies have described that Candida non-albicans are considered as remarkable pathogenic agents of OPC, and among them, C. tropicalis and C. glabrata are known as major strains that may replace C. albicans as the greatest causing agent of this infection [20], [21]. It has been shown that Candida

• Interestingly we found that co treatment with losartan preve

  2025-03-01

  

  Interestingly, we found that co-treatment with losartan prevented the increased participation of ROS from NADPH oxidase on the contractile response to Phe observed in Hg-treated rats. Moreover, losartan also prevented the reduction in the endothelial NO modulation of this response found in treated a

• cdk9 inhibitor It was reported that oral

  2025-03-01

  

  It was reported that oral administration of CSZ to C57BL/6J mice significantly improved spatial learning and memory, and prevented Aβ-induced immunoresponse in Aβ25-35-injected mice. However, post-treatment with CSZ after Aβ25-35 administration, when Aβ was already accumulated, did not prevent Aβ-in

• Introduction AMP activated protein kinase AMPK is mainly kno

  2025-03-01

  

  Introduction AMP-activated protein kinase (AMPK) is mainly known as a highly conserved and ubiquitously expressed energy sensor that is highly sensitive to changes in cellular energy levels (by sensing increases in AMP:ATP and ADP:ATP ratios) and makes appropriate adjustment to balance the consumpt

• In fact serotonin is a major modulator of dopaminergic DA

  2025-03-01

  

  In fact, serotonin is a major modulator of dopaminergic (DA) neuronal activity through the 5-HT2C receptor. Studies have shown that the selective 5-HT2C receptor agonist Ro60-0175 blocks the burst-firing of mesolimbic DA neurons, which project from the ventral tegmental area (VTA) to the nucleus acc

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