• pkg inhibitor In the current study we provide evidence that

  2023-01-10

  

  In the current study, we provide evidence that enhanced ATX activity correlates well with increased ATX protein concentration during cholestasis and pregnancy (Fig. 1). Hereby we have ruled out the possibility of ATX enzyme activation in these conditions, e.g. by circulating cholephiles. ATX clearan

• The AMP Activated Protein Kinase AMPK has evolved as

  2023-01-10

  

  The 5′AMP-Activated Protein Kinase (AMPK) has evolved as an important cellular sensor of reduced energy status that can subsequently phosphorylate its target proteins, slowing the rates of key biosynthetic processes and promoting energy producing pathways; for these reasons AMPK has been proposed as

• Human testicular peritubular cells HTPCs are

  2023-01-09

  

  Human testicular peritubular amg express llc synthesis (HTPCs) are also the only human testicular cell type that can be isolated, cultured and studied in vitro (Albrecht et al., 2006, Mayerhofer, 2013). Results from recent studies indicate that their roles go beyond sperm transport and include immu

• Children with ADA SCID commonly suffer

  2023-01-09

  

  Children with ADA-SCID commonly suffer from a variety of opportunistic infections, including viral, fungal, and mycobacterial infections. Due to defects in l glycine sale and IG production, they are also susceptible to infection with encapsulated bacteria such as Haemophilus influenzae, Streptococc

• The first suggestions that the

  2023-01-09

  

  The first suggestions that the cleaved intracellular domain of APP, AICD, might transit to the nucleus and hence selectively regulate gene transcription arose from analogies with the Notch receptor signalling system where similar intra-membrane proteolysis occurs [84], [85] and it was later confirme

• br In patients with spina bifida

  2023-01-09

  

  In patients with spina bifida and spinal cord injury, fecal incontinence is a serious issue that can impair activities of daily living and patient self-esteem. To address this Malone et al. first described the Antegrade Continence Enema (ACE) procedure in 1990 [1], which achieves continence by all

• DCA australia ASK belongs to the family of

  2023-01-09

  

  ASK1 belongs to the family of MAPKKK. ASK1-mediated apoptosis is involved in the pathogenesis of several diseases such as I/R injury, infectious diseases and neurodegenerative disorders [33], [34], [35]. ASK1 can be activated through different mechanisms. One mechanism is that oxidative stress direc

• br Acknowledgments This study is a

  2023-01-09

  

  Acknowledgments This study is a part of a MSc thesis and supported by Scientific Research Projects Coordination Unit of Akdeniz University (grant number: 2011.02.0122.007). Introduction Apelin receptor (putative receptor protein related to the angiotensin receptor AT1, APJ) belongs to the G-p

• The protein kinase CK mediated phosphorylation of HMGN was

  2023-01-09

  

  The protein kinase CK2-mediated phosphorylation of HMGN1 was implicated to be involved in age-associated amnesia in rats [31]. It was shown that the decreased level of HMGN1 phosphorylation due to the down-regulation of CK2 activity could cause amnesia in aged rats, whereas the treatment with protei

• br AR signaling and urothelial cancer

  2023-01-09

  

  AR signaling and urothelial cancer progression As shown in other types of malignancies, such as prostate cancer cells, it has been documented that androgens induce AR expression and its nuclear translocation as well as ARE promoter activity in urothelial cancer cells (Chen et al., 2003, Izumi et 

• br Obstructing SNARE zippering Sharma et al

  2023-01-09

  

  Obstructing SNARE “zippering” Sharma et al. demonstrated for the first time that in the postmortem AD brains, the level of SNARE complex formation, which is necessary for driving synaptic vesicle fusion at the presynaptic active zone, is significantly reduced [123]. In the absence of changes in e

• Pazopanib Hydrochloride br Results br Discussion Cardiac dys

  2023-01-09

  

  Results Discussion Cardiac dysfunction, common complication of severe sepsis, is one cause of death in intensive care units. Accumulated evidence revealed the regulatory effect of autophagy on sepsis-induced cardiac dysfunction [15], [22], although the mechanisms in young and aging are not elu

• In an attempt to complete the overview of resistance

  2023-01-05

  

  In an attempt to complete the overview of resistance mechanisms in Spanish codling moth populations, the aims of the present work were to assess the actual occurrence of AChE and kdr mutations in codling moth field populations from different pome fruit-growing areas of Spain, concurrently with the f

• The altered frequency of CD T

  2023-01-05

  

  The altered frequency of CD4+ T Chlorogenic acid mg in 5-LO−/− mice led us to hypothesize that these leukocytes could be exerting a primary control of the inflammatory response. In fact, the lack of 5-LO resulted in the accumulation of CD4+CD25+ cells expressing Treg markers. It is plausible to spe

• Whereas more research is needed to identify the precise mech

  2023-01-05

  

  Whereas more research is needed to identify the precise mechanism by which FIN exerts its antidyskinetic effect, the Neochlorogenic acid australia that it can negatively modulate dopaminergic transmission is also supported by our previous findings. Indeed, we have previously shown that FIN complete

15292 records 282/1020 page Previous Next First page 上5页 281282283284285 下5页 Last page