• The identification of distinct expression domains

  2022-07-21

  

  The identification of distinct expression domains in the limb suggested that these domains might have specific biological functions. We explored this possibility by determining enriched biological processes for each category using GO ontology term analysis (WebGestalt) (Zhang et al., 2005). Category

• br Conflict of interest br Transparency

  2022-07-21

  

  Conflict of interest Transparency document Acknowledgements We acknowledge our funding sources from the American Heart Association (13EIA4480016) and the National Institute of Health/National Heart, Lung, and Blood Institute (RO1 HL094414). We are very grateful to Dr. Shaohua Xiao and Dr. S

• Following an endoproteolytic cleavage of C secretase trims t

  2022-07-21

  

  Following an endoproteolytic cleavage of C99, γ-secretase trims the remaining fragment Aβ49 or Aβ48 in successive, mostly three-residue steps. Aβ49 typically gives rise to Aβ46, Aβ43, and Aβ40; whereas Aβ48 usually yields Aβ45 and Aβ42 [59]. The physical basis for this characteristic cleavage patter

• N Alkylated quinolinium dyes are the common

  2022-07-21

  

  N-Alkylated quinolinium dyes are the common fluorescence molecules used in fluorescence sensing and cell imaging because of their attractive optical properties as well as high DNA binding affinities.13, 14, 15, 16, 17, 18, 19, 20 Moreover, the quinolinium moiety usually plays the role of donor in va

• In cardiomyocytes mechanical stress builds

  2022-07-21

  

  In cardiomyocytes mechanical stress builds up via FAs and the related costamere structures, and excessive stress can cause cardiac hypertrophy. Cardoso et al. (2016) report a comprehensive study that demonstrates the link between stress-induced FAK activation and a FAK-mediated initiation of a trans

• TRRAP participates in embryonic development as

  2022-07-20

  

  TRRAP participates in embryonic development, as demonstrated by its binding with proteins regulating the Notch signaling pathway in fruit fly, the Ras signaling pathway in C. elegans, or the Wnt signaling pathway in 293T cells. Therefore we suspect that TRRAP variants, more especially those falling

• Distribution of histamine receptors in the intestines varies

  2022-07-20

  

  Distribution of histamine receptors in the intestines varies among species, but our findings are similar to those previously reported in humans and guinea pigs (Thurmond, 2010, Thurmond, 2015). H1 receptors were located mainly in the gastric mucosa, smooth muscle, and lymphoid tissue, corresponding

• br Ethical approve and consent to

  2022-07-19

  

  Ethical approve and consent to participate Consent for publication Availability of supporting data Competing interests Funding This work was supported by a grant from Key Program of National Natural Science Foundation of China (No. 81330089) and the Shanghai Science and Technology Fun

• Materials and methods br Results br Discussion Since LF is

  2022-07-19

  

  Materials and methods Results Discussion Since LF is a protease, rapid and direct purification is critical for production of functional rLF. Although previous investigators improved the rLF quality by simplifying purification steps, avoiding formation of inclusion body, decreasing degradation

• br Materials and methods br Results br Discussion

  2022-07-19

  

  Materials and methods Results Discussion Directly modulating specific target proteins and signaling pathways with small-molecule drugs or agonistic CBL0137 hydrochloride is widely used for cancer metastasis therapies [[39], [40], [41]]. ANXA7 acts as a metastasis suppressor in prostate can

• br Ketone body metabolism and neuronal excitability One of t

  2022-07-19

  

  Ketone body metabolism and neuronal excitability One of the best examples of the close connection between metabolism and neuronal excitability is illustrated by the effect of ketone bodies on epileptic seizures. One third of patients suffering from epileptic seizures do not respond to conventiona

• br Materials and methods br Results br

  2022-07-19

  

  Materials and methods Results Discussion Although there is general agreement that GPR109A has anti-lipolytic activity and that the NEFA reduction in response to nicotinic Phosphatase Inhibitor Cocktail (2 Tubes, 100X) is mediated by GPR109A, whether GPR109A activation has any impact on pla

• Throughout our studies we used CBD

  2022-07-19

  

  Throughout our studies we used CBD under the assumption that it binds to the GPR55 receptor and has antagonist properties at the GPR55 receptor, as previously suggested (Whyte et al., 2009). To clarify whether the GPR55 receptor is involved in the O-1602-mediated effects on GI motility, we performed

• In order for cytokines to

  2022-07-19

  

  In order for cytokines to exert any effect on the NSC population, they must first bind to specific receptors on the cell surface. Numerous pro- and anti-inflammatory cytokines are able to exert effects on the NSC population, including IL-1β through IL-1R1 and IL-1R2, TNFα through TNFR1 and TNFR2, IL

• glycerophosphate One difficulty in studying gp is that it bi

  2022-07-19

  

  One difficulty in studying gp120 is that it binds to more than one receptor. Understanding how glycerophosphate respond to gp120 is complex because of this promiscuity. In an attempt to establish the contribution of CXCR4 in the antagonistic effect of gp120 on morphine-induced antinociception, AMD3

15307 records 337/1021 page Previous Next First page 上5页 336337338339340 下5页 Last page