• br Materials and methods br Results br

  2019-10-11

  

  Materials and methods Results Discussion Ubiquitination is an important eukaryotic process that defines the fate of proteins and their functionality. It has multiple roles in cell survival, differentiation and development (Glickman and Ciechanover, 2002). Ubiquitination is usually known as

• br Experimental methods br Results and discussion br Conclus

  2019-10-11

  

  Experimental methods Results and discussion Conclusion Rational design of highly selective fluorescent probes to detect G-quadruplexes is of profound importance for basic research. On this basis, we designed and synthesized a series of N-alkylated styrylquinolinium dyes Ls-1, Ls-2 and Ls-3.

• br Experimental br Results and discussion br Conclusions In

  2019-10-11

  

  Experimental Results and discussion Conclusions In this work we presented the direct electrochemical behaviour of the Mo containing formate dehydrogenase, purified from D. desulfuricans, where the Mo centre redox features were observed. The results allowed to calculate the reduction potenti

• Despite low respiratory rates in citrus fruit prolonged

  2019-10-11

  

  Despite low respiratory rates in citrus fruit, prolonged periods of storage may cause significant changes in the levels of organic acids (Echeverria and Valich, 1988). V-ATPase and V-PPase catalyze the electrogenic H+ translocation from the cytosol to the vacuolar lumen to generate an inside-acid pH

• The mutation in Caucasian people of European

  2019-10-11

  

  The Δ32 mutation in Caucasian people of European heritage is quite common but extremely rare in Asian and African countries (Huang et al., 1996). We recently reported the presence of this mutation from India (Husain et al., 1998a) and established the complete inheritance pattern (Husain et al., 1998

• br Conclusion br Acknowledgements br Introduction In

  2019-10-11

  

  Conclusion Acknowledgements Introduction In recent years, fast progress has been made toward using the supercritical technology in industrial separation processes. Apart from a green extraction process that replaces organic solvents, applications involving supercritical fluids include super

• The acids applied in this study

  2019-10-10

  

  The acids applied in this study are commonly used in dental practice. Phosphoric ML-090 is an oxyacid used regularly for adhesion of resin composites. Enamel phosphoric acid etching can dissolve and demineralize the inorganic [Ca10(PO4)6(OH)2] matrix, creating micro pores and microgrooves to improve

• Caspase-2, human recombinant proteinase For the SAR optimiz

  2019-10-10

  

  For the SAR optimization of the right hand side, it was decided to explore the inclusion of the key carboxylic Caspase-2, human recombinant proteinase moiety present in the original DGAT-1 inhibitors from . Analogs were constructed by the synthetic routes outlined in , . In , the methylene-oxy link

• Introduction Formate dehydrogenase enzymes FDHs are a group

  2019-10-10

  

  Introduction Formate dehydrogenase enzymes (FDHs) are a group of heterogeneous proteins that catalyse the reversible formate () oxidation to carbon dioxide () (Eq. (1)). These enzymes are classified in two families, one gathering the enzymes that hold no redox-active centres and another that includ

• The lungs dissected from week mice were cut

  2019-10-10

  

  The lungs dissected from 4–5-week mice were cut into small pieces and then immersed in Dulbecco\'s modified Eagle\'s medium (Invitrogen, Carlsbad, CA) containing collagenase II (2 mg/ml), trypsin (2.5 mg/ml), Dnase I (2 mg/ml), penicillin (100 U/ml), and streptomycin (100 μg/ml) for 12 hours at 37

• Autophagy alterations are frequently reported as one

  2019-10-10

  

  Autophagy alterations are frequently reported as one of the pathological mechanisms contributing to neurodegenerative diseases, due to incomplete removal of protein prostaglandin receptor in the brain [30,41]. It was over a decade ago when mutations in PARK8 encoding for the LRRK2 protein were desc

• We thank Dr Hongqiang Qin at Dalian Institute of

  2019-10-10

  

  We thank Dr. Hongqiang Qin at Dalian Institute of Chemical Physics, Chinese Academy of Sciences for technical assistance in mass-spectrometric analysis. We thank Prof. Quentin Liu at Dalian Medical University and Prof. Qiang Shen at M.D. Anderson Cancer Center for helpful discussion and comments. Dr

• Conversely to the reduction in restraint evoked HR increase

  2019-10-10

  

  Conversely to the reduction in restraint-evoked HR increase following the blockade of CRF receptors, Nijsen et al. [28] demonstrated that BNST treatment with a nonselective CRF Asiatic acid pathway antagonist enhanced the tachycardia evoked by contextual fear conditioning. Taken together, these res

• Koumine br Experimental br Declaration of interest br

  2019-10-10

  

  Experimental Declaration of interest Introduction Material and methods Results and discussion Conclusion By screening the NMR Koumine library an initial hit was found for an inhibitor of the PPI between the α-β subunits of CK2 with an IC50 of 900 μM. This compound was modified and

• br Materials and methods br Results br

  2019-10-10

  

  Materials and methods Results Discussion Taken together with our previous report, our current data demonstrate induction of Chk in monocytes by IL-3, IL-4, IL-13, and GM-CSF ((Musso et al., 1994) and Fig. 1, Fig. 2, Fig. 3, Fig. 4). Chk lipoxygenase inhibitor is also inducible by stem cell

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