• In this section we will try and address many of

  2019-04-26

  

  In this section we will try and address many of the frequently asked questions around preventive and prophylactic measures for patients either starting or already established on bone-targeted therapy (Figs. 2 and 3). In view of the difficulties in treating ONJ, preventive strategies would seem to ma

• br Results Twenty seven bone lesions were

  2019-04-26

  

  Results Twenty-seven bone lesions were analyzed in 27 patients. Twelve of the patients were female and 15 were male. The mean age of the patients was 58 years with a range of 21–84 years. Ten lesions were determined to be malignant and 17 benign. Benign lesions of bone dropped in signal on out-of

• order Tenovin-6 Lead fracture was observed in of leads verif

  2019-04-26

  

  Lead fracture was observed in 4 of 1092 leads (0.37%); verified and incomplete lead fractures were observed in three (0.27%) and one lead (0.09%), respectively. All these fractures occurred in leads implanted by the SVP method; no fractures were observed in leads implanted by the CVC method (p Disc

• dilutions Sadly cytomegalovirus retinitis remains the neglec

  2019-04-25

  

  Sadly, cytomegalovirus retinitis remains the neglected disease of the AIDS pandemic, and there is an increasing group of young patients in low-income and middle-income countries made healthy by successful treatment of underlying HIV, yet left permanently blind from undiagnosed or inadequately treate

• The great American epidemiologist Bill Silverman taught us

  2019-04-25

  

  The great American epidemiologist Bill Silverman taught us that the road to hell is paved with good intentions. From 1942, during a 12-year period, more than 10 000 infants were blinded through retinopathy of prematurity because paediatricians recommended a minor increase in the concentration of sup

• Esta postura foi decisiva para as

  2019-04-25

  

  Esta postura foi decisiva para as alianças confeccionadas pelas lideranças políticas e/ou religiosas (neo) pentecostais nas eleições seguintes. O apoio a Collor em 1989 e a Fernando Henrique Cardoso em 1994 teve como objetivo a oposição ao candidato Lula, do Partido dos Trabalhadores (pt), à Presidê

• One of the unheralded developments in global health is the

  2019-04-25

  

  One of the unheralded developments in global health is the welcome increase in the number of older people (ie, aged 60 or 65 years and older) in low-income and middle-income countries. In parallel with the gains from this longevity dividend, ageing presents particular challenges to health services.

• br Methods The study population comprised

  2019-04-25

  

  Methods The study population comprised 150 patients who underwent implantations of Medtronic dual chamber pacemakers and who had maintained both atrial and ventricular sensing (either in DDD, DDI, or VDD modes) from March 2008 to October 2010. The implanted TW-37 generators were either Kappa ser

• order Rupatadine Fumarate br Discussion and outstanding ques

  2019-04-25

  

  Discussion and outstanding questions Reproductive endocrine hormones such as inhibin affect breast cancer cell survival in the primary tumour and affect tumour homing and survival in the bone microenvironment. The molecular mechanism driving this effect of hormones in bone is likely to be multifa

• glycine transporter Causative genes for ARVC and their respe

  2019-04-25

  

  Causative genes for ARVC and their respective characteristics are summarized in Table 1. Desmosome genes for ARVC Other causative genes for ARVC Although more than half of ARVC patients carry mutations in desmosome genes, other genes have also been reported as causative genes for ARVC (Table

• br As the only methods available for dual

  2019-04-25

  

  As the only methods available for dual protection against pregnancy and sexually transmitted infections (STIs), male and female condoms have a vital role in sexual and reproductive health. Mags Beksinska and colleagues therefore are to be commended for their randomised crossover trial in this BV6

• Haemorrhagic stroke was once a

  2019-04-25

  

  Haemorrhagic stroke was once a major cause of death in high-income nations, but its importance has receded in those regions over the 20th century. Our results suggest that, in the first decade of the 21st century, haemorrhagic stroke remains an important cause of death and disability worldwide. With

• The diagnostic infrastructure in the public sector

  2019-04-25

  

  The diagnostic infrastructure in the public sector relies mainly on sputum smear microscopy that cannot detect drug resistance. It is only when patients fail to get better on standard treatment, or have recurrence of tuberculosis, that they get screened for MDR-TB, resulting in morbidity, continued

• br Genetic basis Similar to other arrhythmia

  2019-04-24

  

  Genetic basis Similar to other arrhythmia syndromes, Brugada and early repolarization syndromes are inherited diseases that are usually transmitted in an autosomal-dominant manner [26]. To date, 13 genes have been associated with Brugada syndrome. Loss-of-function mutations in SCN5A, encoding the

• br How do you manage patients on

  2019-04-24

  

  How do you manage patients on intravenous bone-targeted agents who require dental work? For patients who are on IV bisphosphonate therapy and require dento-alveolar procedures there is a suggestion that prophylactic antibiotic use around the procedure may be helpful in reducing ONJ risk [45,49].

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